Assistant Professor in Pharmacology Question Paper and Answer Key

 PROVISIONAL ANSWER KEY
Question Paper Code: 28/2024/OL
Category Code: 349/2023
Exam: Assistant Professor in Pharmacology
Date of Test 20-03-2024
Department Medical Education

Question1:-Which of the following is an example for supra additive synergism?
        A:-Nitrous oxide + Halothane
        B:-Levodopa + Carbidopa
        C:-Amlodipine + Atenolol
        D:-Glibenclamide + Metformin
        Correct Answer:- Option-B

Question2:-All are examples of pharmacogenetically mediated adverse effects except
        A:-Tardive dyskinesia by neuroleptics
        B:-Acetylator status of isoniazid
        C:-Malignant hyperthermia of halothane
        D:-Acute intermittent porphyria by barbiturates
        Correct Answer:- Option-A

Question3:-All the following molecules act through JAK/STAT receptors except
        A:-Growth hormone
        B:-Interferon
        C:-Cytokine
        D:-Thyroxine
        Correct Answer:- Option-D

Question4:-Which of the following drugs produce phototoxicity?
i.   Amiodarone
ii. Sulfonamides
iii. Phenothiazines
iv. Phenytoin
        A:-(i, ii, iii) only
        B:-(i, iii, iv) only
        C:-(i, ii, iv) only
        D:-(ii, iii, iv) only
        Correct Answer:- Option-A

Question5:-Characteristic features of intramuscular route of drug administration
i.   Hypertonic solution can be injected
ii. Only water solutions can be injected
iii. Oily solutions can be injected
        A:-only i
        B:-only ii
        C:-only iii
        D:-all of the above
        Correct Answer:- Option-C

Question6:-Which of the following statements are correct about Meta-analysis?
i. Cannot prove cause and effect
ii. Evaluation and grouping of similar studies
iii. Aim is to decrease the number of subjects studied
        A:-Only (i and ii)
        B:-Only (i and iii)
        C:-Only (ii & iii)
        D:-All of the above
        Correct Answer:- Option-A

Question7:-Which statement is not true about transdermal therapeutic system?
        A:-provides smooth plasma concentration of the drug
        B:-better patient compliance
        C:-more inter individual variations
        D:-mild local adverse effects
        Correct Answer:- Option-C

Question8:-Among the following combinations which is not a CYP3A4 substrate and its inhibitor?
        A:-Carbamazepine - Clarithromycin
        B:-Simvastatin - Itraconazole
        C:-Losartan - Verapamil
        D:-Metoprolol - Nevirapine
        Correct Answer:- Option-D

Question9:-All are indications of therapeutic drug monitoring except
        A:-Drugs with high inter-individual variation in plasma concentration
        B:-Drugs with irreversible actions
        C:-Monitoring of patient compliance
        D:-Drugs whose therapeutic effect cannot be determined clinically
        Correct Answer:- Option-B

Question10:-Which of the following statements are correct about clinical trial?
i.   Phase I - Dose range, safety and etolerability, only in patients
ii. Phase II - Therapeutic efficacy and dose range in patients
iii. Phase III - Drug safety and tolerability in large number of patients
iv. Phase IV - Therapeutic efficacy in large number of patients
        A:-(i and ii) only
        B:-(ii and iii) only
        C:-(i and iv) only
        D:-(ii and iv) only
        Correct Answer:- Option-B

Question11:-Systemic clearance of a drug is directly related with all the following except
        A:-Bioavailability
        B:-Volume of distribution
        C:-Plasma half-life
        D:-Elimination rate constant
        Correct Answer:- Option-A

Question12:-Which statement is not true about OATP1B1 transporter?
        A:-More than 40 nonsynonymous variants
        B:-Encoded by 8hCO1B1 gene
        C:-Polymorphism increases transport of OATP1B1 substrates
        D:-Responsible for the hepatic uptake of weakly acidic drugs
        Correct Answer:- Option-C

Question13:-Which schedule under the drugs and cosmetics rules, 1945 deals with the prescription of tramadol and pentazocine?
        A:-Schedule C1
        B:-Schedule E1
        C:-Schedule F1
        D:-Schedule H1
        Correct Answer:- Option-D

Question14:-Among the following benzodiazipines which is preferred in elderly individuals?
        A:-Diazepam
        B:-Lorazepam
        C:-Flurazepam
        D:-Midazolam
        Correct Answer:- Option-B

Question15:-Quality Adjusted Life Years (QALYS) is a measure of which pharmaco economic analysis
        A:-Cost-effectiveness analysis
        B:-Cost-minimization analysis
        C:-Cost-utility analysis
        D:-Cost-risk analysis
        Correct Answer:- Option-C

Question16:-Botulinum toxin is beneficial in all except
        A:-age related facial wrinkles
        B:-post operative paralytic ileus
        C:-Spastic cerebral palsy
        D:-Axillary hyper-hydrosis
        Correct Answer:- Option-B

Question17:-Among the following drugs which is not useful in acute congestive glaucoma
        A:-Dipivefrine
        B:-IV Mannitol
        C:-Glycerol
        D:-Acetazolamide
        Correct Answer:- Option-A

Question18:-All are advantages of third generation β blocker Nebivolol except
        A:-Absense of hyperlipidemia
        B:-Increases insulin sensitivity
        C:-Enhances nitric oxide production
        D:-Slow onset of hypotensive response
        Correct Answer:- Option-D

Question19:-All are properties of halothane except
        A:-Potent anaesthetic agent
        B:-Good analgesic agent
        C:-Potentiates competitive neuromuscular blockers
        D:-Can produce cardiotoxicity
        Correct Answer:- Option-B

Question20:-Which adverse effect is more seen with pentazocin than with morphine?
        A:-Biliary spasm
        B:-Constipation
        C:-Hypertension
        D:-Vomiting
        Correct Answer:- Option-C

Question21:-All are AMPA blockers used as antiepileptic drugs except
        A:-Topiramate
        B:-Lamotrigine
        C:-Perampanel
        D:-Felbamate
        Correct Answer:- Option-D

Question22:-Which of the following statement is not true about Agomelatine an atypical antidepressant drug?
        A:-Agonist on MT1 receptor
        B:-Agonist on MT2 receptor
        C:-Antagonist on 5HT2A receptor
        D:-Antagonist on 5HT2C receptor
        Correct Answer:- Option-C

Question23:-All are adverse effects of clozapine which is an atypical antipsycholic agent except
        A:-Agranulocytosis
        B:-Acute muscular dystonia
        C:-Myocarditis
        D:-Metabolic syndrome
        Correct Answer:- Option-B

Question24:-Baclofen is a centrally acting skeletal muscle relaxant used to treat following clinical conditions except
        A:-Amyotropic lateral sclerosis
        B:-Cerebral palsy
        C:-Spinal injuries
        D:-Multiple sclerosis
        Correct Answer:- Option-B

Question25:-All are properties of local anesthetic agent Ropivacaine
i.   Short acting
ii. Less cardiotoxicity
iii. Blocks A8 and C fibres completely
iv. Used epidurally for labour pain
        A:-(i and ii) only
        B:-(i, ii and iii) only
        C:-(ii, iii and iv) only
        D:-All of the above
        Correct Answer:- Option-C

Question26:-Which among the following beta blocker has the longest half life?
        A:-Metaprolol
        B:-Bisoprolol
        C:-Carvedilol
        D:-Propranolol
        Correct Answer:- Option-B

Question27:-Which of the following calcium channel blockers can delay the progression of early stages of type I diabetes by improving the survival of pancreatic beta cells?
        A:-Verapamil
        B:-Diltiazem
        C:-Felodipine
        D:-Cilnidipine
        Correct Answer:- Option-A

Question28:-Choose the drug which attenuates platelet aggregation by antagonising thromboxane receptor :
        A:-Losartan
        B:-Candesartan
        C:-Telmisartan
        D:-Olmesartan
        Correct Answer:- Option-A

Question29:-In patients with diabetes and chronic kidney disease which of the following drugs can reduce heart failure events and renal function decline
        A:-ISDN/Hydralazine
        B:-Ivabradine
        C:-Finerenone
        D:-Levosimendan
        Correct Answer:- Option-C

Question30:-The following antiarrhythmic drug produces anticholinergic side effects
        A:-Procainamide
        B:-Mexiletine
        C:-Disopyramide
        D:-Flecainide
        Correct Answer:- Option-C

Question31:-Which of the following drug is the first line therapy for severe Pulmonary Artery Hypertension (Functional Class IV)
        A:-Treprostinil
        B:-Riociguat
        C:-Ambrisentan
        D:-Epoprostenol
        Correct Answer:- Option-D

Question32:-Idarucizumab is a reversal agent for toxicity due to
        A:-Dabigatran
        B:-Rivaroxaban
        C:-Apixaban
        D:-Betrixaban
        Correct Answer:- Option-A

Question33:-Which of the following antiplatelet drug has rapid onset of action and a circulating half life of 3 to 4 days?
        A:-Abciximab
        B:-Ticagrelor
        C:-Cangrelor
        D:-Vorapaxar
        Correct Answer:- Option-D

Question34:-Evolocumab is a
        A:-Liver microsomal triglyceride transfer protein inhibitor
        B:-ATP-Citrate Lyase Inhibitor
        C:-Proprotein convertase subtilisin/Kexin type 9 inhibitor
        D:-Angiopoietin-Like protein 3 inhibitor
        Correct Answer:- Option-C

Question35:-Thrombopoietin Receptor Agonist (TRAs) preferred in chronic hepatitis C virus (HCV) associated thrombocytopenia
        A:-Romiplostim
        B:-Eltrombopag
        C:-Avatrombopag
        D:-Lusutrombopag
        Correct Answer:- Option-B

Question36:-GnRH agonist which can be given intranasally is
        A:-Goserelin
        B:-Nafarelin
        C:-Deslorelin
        D:-Histrelin
        Correct Answer:- Option-B

Question37:-Which of the following statement regarding methimazole is correct
        A:-is the drug of choice for Graves disease
        B:-Multiple doses need to be given to produce desired effect
        C:-Chance of liver toxicity more than propylthiouracil
        D:-Methimazole is contraindicated in second and third trimester of pregnancy
        Correct Answer:- Option-A

Question38:-Hypoactive Sexual Desire Disorder (HSDD) is treated with :
        A:-Raloxifene
        B:-Toremifene
        C:-Ospemifene
        D:-Bazedoxifene
        Correct Answer:- Option-C

Question39:-Phosphodiesterase 5 (PDE5) inhibitor with maximum duration of action is
        A:-Sildenafil
        B:-Vardenafil
        C:-Tadalafil
        D:-Avanafil
        Correct Answer:- Option-C

Question40:-Anti inflammatory potency is maximum for
        A:-Fludrocortisone
        B:-Prednisolone
        C:-Triamcinolone
        D:-Betamethasone
        Correct Answer:- Option-D

Question41:-Inoperable adrenocortical carcinoma is treated with
        A:-Mitotane
        B:-Etomidate
        C:-Osilodrostat
        D:-Abiraterone acetate
        Correct Answer:- Option-A

Question42:-Which of the following insulin preparation forms multihexameric complexes after sub cutaneous injection?
        A:-Detemir
        B:-Glargine
        C:-Degludec
        D:-Glulisine
        Correct Answer:- Option-C

Question43:-The GLP-1 agonist approved for weight loss independent of diabetes status are
i.   Dulaglutide
ii. Liraglutide
iii. Lixisenatide
iv. Semaglutide
        A:- only (i and ii)
        B:-only (i and iii)
        C:-only (ii and iv)
        D:-only (i and iv)
        Correct Answer:- Option-C

Question44:-The following bisphosphonate is preferred in treatment of hypercalcemia because of its more rapid normalization of serum and longer duration of action
        A:-Pamidronate
        B:-Ibandronate
        C:-Risedronate
        D:-Zoledronate
        Correct Answer:- Option-D

Question45:-The Vitamin D analogue used in the treatment of Psoriasis is
        A:-Calcipotriol
        B:-Paricalcitol
        C:-Calcitriol
        D:-Calcifediol
        Correct Answer:- Option-A

Question46:-Diagnostic testing of cancer specimen for BRAF V 600 mutation is important in guiding treatment decision for the following drug
        A:-Ceritinib
        B:-Trametinib
        C:-Crizotinib
        D:-Afatinib
        Correct Answer:- Option-B

Question47:-Most neurotoxic alkylating agent is
        A:-Ifosfamide
        B:-Carmustine
        C:-Melphalan
        D:-Busulfan
        Correct Answer:- Option-A

Question48:-Which of the following drug is a very potent radiosensitizer and should not be used with radiotherapy?
        A:-Decitabine
        B:-Capecitabine
        C:-Gemcitabine
        D:-Cytarabine
        Correct Answer:- Option-C

Question49:-Pancreatic Neuro Endocrine Tumor is treated with
        A:-Sorafenib
        B:-Pazopanib
        C:-Axitinib
        D:-Sunitinib
        Correct Answer:- Option-D

Question50:-Abiraterone is used for the treatment of
        A:-Metastatic renal cell cercinoma
        B:-Metastatic prostate cancer
        C:-Metastatic breast cancer
        D:-Metastatic colon cancer
        Correct Answer:- Option-B

Question51:-Bedaquiline acts by
        A:-Inhibiting mycolic acid synthesis
        B:-Inhibiting DNA dependent RNA polymerase
        C:-Inhibiting squalene epoxidase
        D:-Inhibiting Adenosine 5'triphosphate synthase in mycobacteria
        Correct Answer:- Option-D

Question52:-Guanosine analogue with antiretroviral action is
        A:-Zidovudine
        B:-Emixtricitabine
        C:-Abacavir
        D:-Lamivudine
        Correct Answer:- Option-C

Question53:-Orally effective antifungal antibiotic capable of inducing microsomal enzymes is
        A:-Griseofulvin
        B:-Caspofungin acetate
        C:-Posaconazole
        D:-Terbinafine
        Correct Answer:- Option-A

Question54:-An orange dye which exerts analgesic action in urinary tract is
        A:-Nitrofurantoin
        B:-Methenamine
        C:-Phenazopyridine
        D:-Mandelic acid
        Correct Answer:- Option-C

Question55:-Advantages of Artemisinin based combination therapy include all except
        A:-Rapid clinical and parasitological cure
        B:-Good tolerability profile
        C:-High recrudescence rate
        D:-Absence of parasite resistance
        Correct Answer:- Option-C

Question56:-All are true about Linezolid EXCEPT
        A:-It is bactericidal against enterococci
        B:-It acts on 23S rRNA fraction of 50S ribosomal subunit
        C:-It has nearly 100% oral bioavailability
        D:-Thrombocytopenia is a common adverse effect
        Correct Answer:- Option-A

Question57:-Minocycline, in comparison to Doxycycline,
        A:-Attains higher concentration in tears and saliva
        B:-Exhibits poor activity against mycobacterium leprae
        C:-Exhibits higher incidence of photosensitivity
        D:-Does not undergo extensive hepatic metabolism
        Correct Answer:- Option-A

Question58:-The antimicrobial agent effective against pseudomonas is
        A:-Cefazolin
        B:-Ticarcillin
        C:-Tigercycline
        D:-Ampicillin
        Correct Answer:- Option-B

Question59:-Topically effective sulphonamide preparation for bacterial conjunctivities is
        A:-Sulfasalazine
        B:-Sulfadiazine
        C:-Sodium Sulfacetamide
        D:-Sulfadoxine
        Correct Answer:- Option-C

Question60:-Orally effective carbapenem, resistant to inactivation by renal dehydropeptidase is
        A:-Imipenem
        B:-Ertapenem
        C:-Doripenem
        D:-Faropenem
        Correct Answer:- Option-D

Question61:-The mismatched pair among the following is
        A:-Tiotropium bromide - Bronchodilator
        B:-Ketotifen - PAF antagonist
        C:-Pranlukast - Leukotriene synthesis inhibitor
        D:-Omalizumab - Recombinant humanised anti IgE Monoclonal Antibody
        Correct Answer:- Option-C

Question62:-All are uses of N Acetyl Cysteine except
        A:-Captopril induced dry cough
        B:-Dry Eyes
        C:-Acute paracetamol poisoning
        D:-Cyclophosphamide induced haemorrahagic cystitis
        Correct Answer:- Option-A

Question63:-The CCK1/CCKA receptor antagonist that increases motility of the gastrointestinal tract is
        A:- Sodium Alginate
        B:-Lubiprostone
        C:-Magaldrate
        D:-Loxiglumide
        Correct Answer:- Option-D

Question64:-New formula for WHO-ORS provides
        A:-133 mM , 13mM , 98 mM
        B:-75 mM , 20mM , 65 mM
        C:-130 mM , 4mM , 109 mM
        D:-85 mM , 13 mM , 90 mM
        Correct Answer:- Option-B

Question65:-Emesis is induced by
        A:-Aprepitant
        B:-Nabilone
        C:-Cyclizine
        D:-Ipecacuanha
        Correct Answer:- Option-D

Question66:-Active form of the Enkephalinase inhibitor, Racecadotril is
        A:-Pinaverium
        B:-Thiorphan
        C:-Trimebutine
        D:-Crofelemer
        Correct Answer:- Option-B

Question67:-In Rheumatoid arthritis, Anakinra acts by
        A:-Interleukin 1 receptor antagonism
        B:-Inhibition of Calcineurin
        C:-Interleukin 6 receptor antagonism
        D:-Tumour necrosis factor alpha antagonism
        Correct Answer:- Option-A

Question68:-Alprostadil effective in Erectile dysfunction in males is a
        A:- analogue
        B:- analogue
        C:- analogue
        D:- analogue
        Correct Answer:- Option-D

Question69:-Longest acting agonist is
        A:-Naratriptan
        B:-Frovatriptan
        C:-Zolmitriptan
        D:-Rizatriptan
        Correct Answer:- Option-B

Question70:-The true statement about probenecid is
        A:-It is used in patients with gout and nephrolithiasis
        B:-It should be taken with plenty of fluids
        C:-Peptic ulcer is not a contraindication for its use
        D:-It is effective in patients with serum creatinine more than 2 mg/dl.
        Correct Answer:- Option-B

Question71:-Orally effective drug in scabies is
        A:-Permethrin
        B:-Crotamiton
        C:-Ivermectin
        D:-Benzyl benzoate
        Correct Answer:- Option-C

Question72:-Drug effective in treatment of Vitiligo is
        A:-Trioxsalen
        B:-Hydroquinone
        C:-Monobenzone
        D:-Adapalene
        Correct Answer:- Option-A

Question73:-Nephrotoxicity is less common with the use of
        A:-Amphotericin B
        B:-Cyclosporine
        C:-Tacrolimus
        D:-Sirolimus
        Correct Answer:- Option-D

Question74:-Immunostimulant action is exhibited by
        A:-Levamisole
        B:-Methotrexate
        C:-Azathioprine
        D:-Pentostatin
        Correct Answer:- Option-A

Question75:-Lowering of intraocular pressure is seen with the use of
        A:-Tropicamide
        B:-Neostigmine
        C:-Tafluprost
        D:-Cyclopentolate
        Correct Answer:- Option-C

Question76:-Dimercaprol is contraindicated in
        A:-Lead poisoning
        B:-Cadmium poisoning
        C:-Mercury poisoning
        D:-Arsenic poisoning
        Correct Answer:- Option-B

Question77:-Povidone lodine is an example for
        A:-Oxidising agent
        B:-Anionic surfactant
        C:-Dye
        D:-Iodophore
        Correct Answer:- Option-D

Question78:-Find the wrong pair
        A:-Alemtuzumab - CD52
        B:-Gemtuzumab -CD3
        C:-Muromonab-CD3
        D:-Rituximab-CD20
        Correct Answer:- Option-B

Question79:-Read the assertion and reason statements and choose the single best response
Assertion (A) : Sildenafil causes impaired blue green discrimination
Reason (R): Sildenafil is a weak inhibitor of phosphodiesterase 6
        A:-Both (A) and (R) are true and (R) is the correct explanation of (A)
        B:-Both (A) and (R) are true but (R) is not the correct explanation of (A)
        C:-(A) is true and (R) is false
        D:-Both (A) and (R) are false
        Correct Answer:- Option-A

Question80:-False statement about lorcaserin is
        A:-It is a agonist
        B:-It has appetite suppressant action
        C:-It is a cannabinoid receptor antagonist
        D:-Headache, Dizziness, Dry mouth can occur as an adverse effect
        Correct Answer:- Option-C

Question81:-Experimental animal commonly used for pyrogen testing
        A:-Guineapig
        B:-Mouse
        C:-Rabbit
        D:-Rat
        Correct Answer:- Option-C

Question82:-According to prevention of Cruelty to Animals Act 1960, definition of 'animal' includes all except
        A:-Cockroach
        B:-Human beings
        C:-Rat
        D:-Monkey
        Correct Answer:- Option-B

Question83:-Sodium dihydrogen phosphate is a constituent of
        A:-De Jalon's solution
        B:-Frog ringer solution
        C:-Kerbs solution
        D:-Tyrode solution
        Correct Answer:- Option-D

Question84:-Which of the anesthetic agents is not suitable for the study of cardiovascular drugs in experimental animals
        A:-Chloralose
        B:-Ketamine
        C:-Pentobarbitone
        D:-Urethane
        Correct Answer:- Option-C

Question85:-Which among the following can be used as a mobile phase in normal phase HPLC?
        A:-Acetonitrile
        B:-Chloroform
        C:-Methanol
        D:-Water
        Correct Answer:- Option-B

Question86:-Which among the following is not used as a label in Radioimmunoassay
        A:-Carbon-14
        B:-Iodine-125
        C:-Iodine-127
        D:-Iodine-131
        Correct Answer:- Option-C

Question87:-Mean total cholesterol values of 50 diabetic patients is 346 mg/dl with standard deviation of 20 and that of non-diabetics is 288 mg/dl with standard deviation 9. To compare these values, which statistical test is the most appropriate?
        A:-Independent sample t test
        B:-One sample t test
        C:-Median test
        D:-ANOVA
        Correct Answer:- Option-A

Question88:-According to the empirical rule, approximately what percentage of the date should lie within +/-2SD
        A:-68%
        B:-75%
        C:-95%
        D:-99.7%
        Correct Answer:- Option-C

Question89:-If the data are normally distributed with a mean of 180 and standard deviation of 40. Between what two values will approximately 68% of the data fall
        A:-140 and 220
        B:-100 and 260
        C:-60 and 300
        D:-30 and 120
        Correct Answer:- Option-A

Question90:-In a box and whisker plot, two sides of the box represent
        A:- and percentiles
        B:- and percentages
        C:- and percentiles
        D:- and percentiles
        Correct Answer:- Option-D

Question91:-Bradykinin receptor antagonist useful for symptomatic treatment of hereditary angioedema
        A:-Ambristentan
        B:-Donidalorsen
        C:-Ecallantide
        D:-Icatibant
        Correct Answer:- Option-D

Question92:-An endocrine disrupting chemical is
        A:-Aflatoxin B1
        B:-Chromium
        C:-Dichlorodiphenyltrichloroethane (DDT)
        D:-Tetrachlorodibenzo-p-dioxin(TCDD)
        Correct Answer:- Option-C

Question93:-The preferred drug in type 2 diabetes mellitus patient with patient with cardiac failure
        A:-Empagliflozin
        B:-Nateglinide
        C:-Sitagliptin
        D:-Voglibose
        Correct Answer:- Option-A

Question94:-Which among the following is not an example of drug repurposing?
        A:-Minoxidil for treatment of baldness
        B:-Sildenafil for treatment of erectile dysfunction
        C:-Thalidomide for multiple myeloma treatment
        D:-Topiramate for treatment of epilepsy
        Correct Answer:- Option-D

Question95:-Which among the statements regarding Semaglutide is incorrect?
        A:-it is administered subcutaneously
        B:-it causes weight gain in patients
        C:-it has GLP-1 like action
        D:-pancreatitis is an adverse effect
        Correct Answer:- Option-B

Question96:-The drug useful for controlling delusions, hallucinations and psychosis in parkinson's disease
        A:-Opicapone
        B:-Pimavanserin
        C:-Rotigotine
        D:-Safinamide
        Correct Answer:- Option-B

Question97:-Which among the following is not included in world Health Organisation's prescribing indicators
        A:-Percentage of encounters with tablets prescribed
        B:-Percentage of medicines prescribed by generic name
        C:-Percentage of encounters with an antibiotic prescribed
        D:-Percentage of medicines prescribed from essential medicines list
        Correct Answer:- Option-A

Question98:-Which among the following is a Watch drug as per Aware classification of antimicrobials?
        A:-Azithromycin
        B:-Gentamicin
        C:-Pencillin
        D:-Meropenem
        Correct Answer:- Option-A

Question99:-The partial nicotine receptor agonist useful in smoking cessation
        A:-Bupropion
        B:-Rimonabant
        C:-Varenicline
        D:-None of the above
        Correct Answer:- Option-C

Question100:-The assumed average maintenance dose per day for a drug used for its main indication in adults is
        A:-Defined daily dose
        B:-Therapeutic range
        C:-Therapeutic window
        D:-Therapeutic dose
        Correct Answer:- Option-A